Studies on carcinogenic and toxic effects of ochratoxin A in chicks

Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE...

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Veröffentlicht in:	Toxins 2010-04, Vol.2 (4), p.649-664
1. Verfasser:	Stoev, Stoycho D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Chickens Female Kidney - drug effects Kidney - pathology Kidney Neoplasms - chemically induced Kidney Neoplasms - pathology Kidneys Liver - drug effects Liver - pathology Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - pathology Male Mycotoxins - toxicity Neoplasms, Experimental - chemically induced Ochratoxin A Ochratoxins - toxicity
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Zusammenfassung:	Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver.
ISSN:	2072-6651 2072-6651
DOI:	10.3390/toxins2040649