Genetic associations with sporadic neuroendocrine tumor risk

Genetic risk factors for sporadic neuroendocrine tumors (NET) are poorly understood. We tested risk associations in patients with sporadic NET and non-cancer controls, using a custom array containing 1536 single-nucleotide polymorphisms (SNPs) in 355 candidate genes. We identified 18 SNPs associated...

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Veröffentlicht in:	Carcinogenesis (New York) 2011-08, Vol.32 (8), p.1216-1222
Hauptverfasser:	Ter-Minassian, Monica, Wang, Zhaoxi, Asomaning, Kofi, Wu, Michael C., Liu, Chen-Yu, Paulus, Jessica K., Liu, Geoffrey, Bradbury, Penelope A., Zhai, Rihong, Su, Li, Frauenhoffer, Christine S., Hooshmand, Susanne M., De Vivo, Immaculata, Lin, Xihong, Christiani, David C., Kulke, Matthew H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Apoptosis Apoptosis Regulatory Proteins - genetics Biological and medical sciences Biomarkers, Tumor - genetics Carcinogenesis, carcinogens and anticarcinogens Case-Control Studies Female Gene Expression Profiling Genetic Predisposition to Disease Genotype Humans Interleukin-12 Subunit p35 - genetics Male Medical sciences Membrane Proteins - genetics Middle Aged Molecular Epidemiology Neuroendocrine Tumors - genetics Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Polymorphism, Single Nucleotide - genetics Prognosis Risk Factors Tumors Young Adult
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Zusammenfassung:	Genetic risk factors for sporadic neuroendocrine tumors (NET) are poorly understood. We tested risk associations in patients with sporadic NET and non-cancer controls, using a custom array containing 1536 single-nucleotide polymorphisms (SNPs) in 355 candidate genes. We identified 18 SNPs associated with NET risk at a P-value
ISSN:	0143-3334 1460-2180
DOI:	10.1093/carcin/bgr095