Structures of the rat complement regulator CrrY

Complement receptor 1‐related protein Y (CrrY) is an important cell‐surface regulator of complement that is unique to rodent species. The structure of rat CrrY domains 1–4 has been determined in two distinct crystal forms and reveals a 70° bend between domains 3 and 4. Comparisons of this structure...

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Veröffentlicht in:	Acta crystallographica. Section F, Structural biology and crystallization communications Structural biology and crystallization communications, 2011-07, Vol.67 (7), p.739-743
Hauptverfasser:	Roversi, Pietro, Johnson, Steven, Caesar, Joseph J. E., McLean, Florence, Leath, Kirstin J., Tsiftsoglou, Stefanos A., Morgan, B. Paul, Harris, Claire L., Sim, Robert B., Lea, Susan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Surface - chemistry CCP Complement complement regulator CrrY Crystal structure Crystallography Crystallography, X-Ray Forming Humans Models, Molecular Protein Structure, Tertiary Proteins rat Rats Receptors Receptors, Cell Surface - chemistry Regulators Rodents Structural Communications Structural Homology, Protein
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Beschreibung
Zusammenfassung:	Complement receptor 1‐related protein Y (CrrY) is an important cell‐surface regulator of complement that is unique to rodent species. The structure of rat CrrY domains 1–4 has been determined in two distinct crystal forms and reveals a 70° bend between domains 3 and 4. Comparisons of this structure with those of other complement regulators suggests that rearrangement of this interface may occur on forming the regulatory complex with C3b.
ISSN:	1744-3091 1744-3091 2053-230X
DOI:	10.1107/S1744309111016551