Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans

Three other single-nucleotide polymorphisms (SNP) located in intron 3 of STAT4 (rs8179673, rs10181656, rs6752770), three SNP in strong linkage disequilibrium with rs7574865 (r2=1.0; rs7582694, rs7568275, rs11889341) and a haplotype driven by the T allele of rs7574865 are also associated with RA susc...

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Veröffentlicht in:	Annals of the rheumatic diseases 2010-04, Vol.69 (4), p.625-779
Hauptverfasser:	Kelley, James M, Hughes, Laura B, Malik, Ashima, Danila, Maria I, Edberg, Yuanqing, Alarcón, Graciela S, Conn, Doyt L, Jonas, Beth L, Callahan, Leigh F, Smith, Edwin A, Brasington, Richard D, Edberg, Jeffrey C, Kimberly, Robert P, Moreland, Larry W, Bridges, S Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Arthritis, Rheumatoid - genetics Asian People - genetics Biological and medical sciences Black or African American - genetics Diseases of the osteoarticular system Genealogy Genetic Predisposition to Disease Humans Inflammatory joint diseases Medical sciences Polymorphism, Single Nucleotide Population Rheumatoid arthritis STAT4 Transcription Factor - genetics Studies White People - genetics
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Zusammenfassung:	Three other single-nucleotide polymorphisms (SNP) located in intron 3 of STAT4 (rs8179673, rs10181656, rs6752770), three SNP in strong linkage disequilibrium with rs7574865 (r2=1.0; rs7582694, rs7568275, rs11889341) and a haplotype driven by the T allele of rs7574865 are also associated with RA susceptibility. 1 Association with rs7574865 replicated in several Asian and European-based populations (see table 1 ).
ISSN:	0003-4967 1468-2060
DOI:	10.1136/ard.2009.113183