Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain

Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain

In this study, ascorbate (Asc) and glutathione (GSH) concentrations were quantified noninvasively using double‐edited 1H MRS at 4 T in the occipital cortex of healthy young [age (mean ± standard deviation) = 20.4 ± 1.4 years] and elderly (age = 76.6 ± 6.1 years) human subjects. Elderly subjects had...

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Veröffentlicht in:NMR in biomedicine 2011-08, Vol.24 (7), p.888-894
Hauptverfasser: Emir, Uzay E., Raatz, Susan, McPherson, Susan, Hodges, James S., Torkelson, Carolyn, Tawfik, Pierre, White, Tonya, Terpstra, Melissa
Format: Artikel
Sprache:eng
Schlagworte:
Age
Aged
Aged, 80 and over
aging
Animals
ascorbate
Ascorbic acid
Ascorbic Acid - metabolism
Brain
Cortex (occipital)
Electron transport
Geriatrics
Glutathione
Glutathione - metabolism
human
Humans
lactate
Lactic acid
Lactic Acid - metabolism
Magnetic Resonance Spectroscopy - methods
MEGA-PRESS
Mitochondria
MRS
N.M.R
Occipital Lobe - anatomy & histology
Occipital Lobe - metabolism
Young Adult
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Zusammenfassung:In this study, ascorbate (Asc) and glutathione (GSH) concentrations were quantified noninvasively using double‐edited 1H MRS at 4 T in the occipital cortex of healthy young [age (mean ± standard deviation) = 20.4 ± 1.4 years] and elderly (age = 76.6 ± 6.1 years) human subjects. Elderly subjects had a lower GSH concentration than younger subjects (p 
ISSN:0952-3480
1099-1492
1099-1492
DOI:10.1002/nbm.1646