Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation

Large-scale pharmacogenetics and complex disease association studies will require typing of thousands of single-nucleotide polymorphisms (SNPs) in thousands of individuals. Such projects would benefit from a genotyping system with accuracy >99% and a failure rate

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Bibliographische Detailangaben
Veröffentlicht in:	Genome research 2000-03, Vol.10 (3), p.330-343
Hauptverfasser:	Mein, C A, Barratt, B J, Dunn, M G, Siegmund, T, Smith, A N, Esposito, L, Nutland, S, Stevens, H E, Wilson, A J, Phillips, M S, Jarvis, N, Law, S, de Arruda, M, Todd, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Diabetes Mellitus, Type 1 - genetics Endodeoxyribonucleases - chemistry Flap Endonucleases Genetic Predisposition to Disease Genetic Testing - instrumentation Genetic Testing - methods Genotype Humans Methods Molecular Sequence Data Oligonucleotide Probes - chemistry Polymerase Chain Reaction - instrumentation Polymerase Chain Reaction - methods Polymorphism, Single Nucleotide - genetics Sequence Analysis, DNA - instrumentation Sequence Analysis, DNA - methods Spectrometry, Fluorescence Templates, Genetic
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Beschreibung
Zusammenfassung:	Large-scale pharmacogenetics and complex disease association studies will require typing of thousands of single-nucleotide polymorphisms (SNPs) in thousands of individuals. Such projects would benefit from a genotyping system with accuracy >99% and a failure rate
ISSN:	1088-9051 1549-5469
DOI:	10.1101/gr.10.3.330