Bacterial contig map of the 21q11 region associated with Alzheimer's disease and abnormal myelopoiesis in Down syndrome

We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11-q21, encompassing the region of elevated disomic homozygosity in Down Syndrome-associated abnormal myelopoiesis and leukemia, as well as the markers, which has shown a strong association with Alzheim...

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Veröffentlicht in:	Genome research 1998-04, Vol.8 (4), p.385-398
Hauptverfasser:	Groet, J, Ives, J H, South, A P, Baptista, P R, Jones, T A, Yaspo, M L, Lehrach, H, Potier, M C, Van Broeckhoven, C, Nizetić, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Bacteriophage P1 - genetics Blotting, Southern Chromosome Mapping Chromosomes, Artificial, Yeast - genetics Chromosomes, Bacterial - genetics Chromosomes, Human, Pair 21 - genetics DNA, Bacterial - analysis Down Syndrome - genetics Genes Humans Letters Leukopoiesis - genetics Restriction Mapping Sequence Homology, Nucleic Acid
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Zusammenfassung:	We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11-q21, encompassing the region of elevated disomic homozygosity in Down Syndrome-associated abnormal myelopoiesis and leukemia, as well as the markers, which has shown a strong association with Alzheimer's Disease that has never been explained. The map contains 89 overlapping PACs, BACs, or cosmids in three contigs (850, 850, and 1500 kb) with two gaps (one of 140-210 kb and the second
ISSN:	1088-9051 1549-5469
DOI:	10.1101/gr.8.4.385