Enantioselective Dichlorination of Allylic Alcohols

The development of an enantioselective allylic alcohol dichlorination catalyzed by dimeric cinchona alkaloid derivatives and employing aryl iododichlorides as chlorine sources is reported. Reaction optimization, exploration of the substrate scope, and a model for stereoinduction are presented.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2011-06, Vol.133 (21), p.8134-8137
Hauptverfasser:	Nicolaou, K. C, Simmons, Nicholas L, Ying, Yongcheng, Heretsch, Philipp M, Chen, Jason S
Format:	Artikel
Sprache:	eng
Schlagworte:	Allyl Compounds - chemistry Chlorine - chemistry Cinchona Alkaloids - chemistry Propanols - chemistry Stereoisomerism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The development of an enantioselective allylic alcohol dichlorination catalyzed by dimeric cinchona alkaloid derivatives and employing aryl iododichlorides as chlorine sources is reported. Reaction optimization, exploration of the substrate scope, and a model for stereoinduction are presented.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja202555m