Reanalysis of Coreceptor Tropism in HIV-1—Infected Adults Using a Phenotypic Assay with Enhanced Sensitivity

The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell...

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Veröffentlicht in:	Clinical infectious diseases 2011-04, Vol.52 (7), p.925-928
Hauptverfasser:	Wilkin, Timothy J., Goetz, Mathew Bidwell, Leduc, Robert, Skowron, Gail, Su, Zhaohui, Chan, Ellen S., Heera, Jayyant, Chapman, Doug, Spritzler, John, Reeves, Jacqueline D., Gulick, Roy M., Coakley, Eoin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults AIDS Arts BRIEF REPORT Cells Clinical research Clinical trials Genotype & phenotype HIV HIV 1 HIV Infections - virology HIV-1 - physiology HIV/AIDS Human immunodeficiency virus Humans Infections Infectious diseases Patients Receptors, CCR5 - metabolism Receptors, CXCR4 - metabolism Receptors, HIV - metabolism RNA T cell receptors Tropisms Viral Tropism Virology - methods Virus Attachment Viruses
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Zusammenfassung:	The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CSCR4-using virus in all cohorts.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/cir072