Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists

Highlight ► We demonstrate that PPAR-γ agonists protect neurons and microglia from ethanol induced neuropathology in primary cultures and in a novel in vivo mouse model of FASD.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2011-06, Vol.25 (Suppl 1), p.S137-S145
Hauptverfasser:	Kane, Cynthia J.M, Phelan, Kevin D, Han, Lihong, Smith, Renea R, Xie, Jin, Douglas, James C, Drew, Paul D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohol abuse Alcoholism Allergy and Immunology Analysis of Variance Animals Brain - drug effects Brain - metabolism Brain - pathology Cell Count Cell Survival - drug effects Cells, Cultured Cerebellar granule cell Disease Models, Animal Ethanol - pharmacology Female Fetal alcohol spectrum disorders Fetal Alcohol Spectrum Disorders - drug therapy Fetal Alcohol Spectrum Disorders - metabolism Fetal Alcohol Spectrum Disorders - pathology Fetal alcohol syndrome Mice Mice, Inbred C57BL Microglia - drug effects Microglia - metabolism Microglia - pathology Microglial cells Neurodegeneration Neurodevelopment Neurons - drug effects Neurons - metabolism Neurons - pathology Neurotoxicity Nuclear receptors Pioglitazone PPAR gamma - agonists PPAR gamma - pharmacology PPAR gamma - therapeutic use PPAR-γ Pregnancy Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - pharmacology Prostaglandin D2 - therapeutic use Psychiatry Purkinje cell Therapeutics Thiazolidinediones - pharmacology Thiazolidinediones - therapeutic use
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Beschreibung
Zusammenfassung:	Highlight ► We demonstrate that PPAR-γ agonists protect neurons and microglia from ethanol induced neuropathology in primary cultures and in a novel in vivo mouse model of FASD.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2011.02.016