Three-Component Synthesis of Cyclic Enaminones via Ketene Cyclization

Three-Component Synthesis of Cyclic Enaminones via Ketene Cyclization

Cyclic six-membered enaminones were synthesized from three components (bromodiazoacetone, primary amine, and alkyne) in high yields via aza-Michael addition, Wolff rearrangement, and nucleophilic ketene cyclization.

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Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2011-05, Vol.13 (9), p.2147-2149
Hauptverfasser: Seki, Hajime, Georg, Gunda I
Format: Artikel
Sprache:eng
Schlagworte:
Azo Compounds - chemistry
Cyclization
Ethylenes - chemistry
Ketones - chemical synthesis
Ketones - chemistry
Molecular Structure
Stereoisomerism
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Beschreibung
Zusammenfassung:Cyclic six-membered enaminones were synthesized from three components (bromodiazoacetone, primary amine, and alkyne) in high yields via aza-Michael addition, Wolff rearrangement, and nucleophilic ketene cyclization.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol200358h