The MYH9/APOL1 region and chronic kidney disease in European-Americans

Polymorphisms in the MYH9 and adjacent APOL1 gene region demonstrate a strong association with non-diabetic kidney disease in African-Americans. However, it is not known to what extent these polymorphisms are present in other ethnic groups. To examine the association of genetic polymorphisms in this...

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Veröffentlicht in:	Human molecular genetics 2011-06, Vol.20 (12), p.2450-2456
Hauptverfasser:	O'Seaghdha, Conall M, Parekh, Rulan S, Hwang, Shih-Jen, Li, Man, Köttgen, Anna, Coresh, Josef, Yang, Qiong, Fox, Caroline S, Kao, W H Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	Association Studies Cohort Studies European Continental Ancestry Group - genetics Gene Frequency Genetic Predisposition to Disease - genetics Genome-Wide Association Study Genotype Humans Kidney Diseases - ethnology Kidney Diseases - genetics Models, Biological Molecular Motor Proteins - genetics Myosin Heavy Chains - genetics Polymorphism, Single Nucleotide - genetics United States
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Beschreibung
Zusammenfassung:	Polymorphisms in the MYH9 and adjacent APOL1 gene region demonstrate a strong association with non-diabetic kidney disease in African-Americans. However, it is not known to what extent these polymorphisms are present in other ethnic groups. To examine the association of genetic polymorphisms in this region with chronic kidney disease (CKD; estimated glomerular filtration rate
ISSN:	0964-6906 1460-2083
DOI:	10.1093/hmg/ddr118