LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese
AIM： To explore the associations of polymorphisms of lipopolysaccharide binding protein （LBP）, cluster of differentiation 14 （CD14）, toll-like receptor 4 （TLR-4）, interleukin-6 （IL-6） and tumor necrosis factor α （TNF-α） with the colorectal carcinoma （CRC） risk in Han Chinese. METHODS： Polymorphisms...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2011-05, Vol.17 (18), p.2326-2331 |
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| creator | Chen, Rui Luo, Fu-Kang Wang, Ya-Li Tang, Jin-Liang Liu, You-Sheng |
| description | AIM： To explore the associations of polymorphisms of lipopolysaccharide binding protein （LBP）, cluster of differentiation 14 （CD14）, toll-like receptor 4 （TLR-4）, interleukin-6 （IL-6） and tumor necrosis factor α （TNF-α） with the colorectal carcinoma （CRC） risk in Han Chinese. METHODS： Polymorphisms of LBP （rs1739654, rs223 2596, rs2232618）, CD14 （rs77083413, rs4914）, TLR-4 （rs5030719）, IL-6 （rs13306435） and TNF-α （rs35131721） were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms （SNPs） between cases and controls were analyzed by unconditional logistic regression. RESULTS： GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk ofCRC [odds ratio （OR） = 1.51, 95% confidence interval （CI） 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 （OR= 1.69, 95% CI 1.20-2.36, P = 0.002）. In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC （OR = 3.44, 95% CI 1.94-6.10, P = 0.000）. CONCLUSION： This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population. |
| doi_str_mv | 10.3748/wjg.v17.i18.2326 |
| format | Article |
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METHODS： Polymorphisms of LBP （rs1739654, rs223 2596, rs2232618）, CD14 （rs77083413, rs4914）, TLR-4 （rs5030719）, IL-6 （rs13306435） and TNF-α （rs35131721） were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms （SNPs） between cases and controls were analyzed by unconditional logistic regression. RESULTS： GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk ofCRC [odds ratio （OR） = 1.51, 95% confidence interval （CI） 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 （OR= 1.69, 95% CI 1.20-2.36, P = 0.002）. In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC （OR = 3.44, 95% CI 1.94-6.10, P = 0.000）. CONCLUSION： This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v17.i18.2326</identifier><identifier>PMID: 21633598</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Co., Limited</publisher><subject>Acute-Phase Proteins - genetics ; Adult ; Aged ; Asian Continental Ancestry Group - genetics ; Carrier Proteins - genetics ; Case-Control Studies ; CD14 ; Colorectal Neoplasms - genetics ; DNA Primers - chemistry ; Female ; Humans ; LBP ; Lipopolysaccharide Receptors - genetics ; logistic回归分析 ; Male ; Membrane Glycoproteins - genetics ; Middle Aged ; Original ; Polymorphism, Single Nucleotide ; Risk Factors ; Toll样受体4 ; 中国汉族人群 ; 基因多态性 ; 大肠癌 ; 风险</subject><ispartof>World journal of gastroenterology : WJG, 2011-05, Vol.17 (18), p.2326-2331</ispartof><rights>2011 Baishideng Publishing Group Co., Limited. All rights reserved. 2011</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-c75b1cb0403ca9bd983f6bb8161dacd13db92d280b7c24fc8e5f7190878233b13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098400/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098400/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21633598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Rui</creatorcontrib><creatorcontrib>Luo, Fu-Kang</creatorcontrib><creatorcontrib>Wang, Ya-Li</creatorcontrib><creatorcontrib>Tang, Jin-Liang</creatorcontrib><creatorcontrib>Liu, You-Sheng</creatorcontrib><title>LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To explore the associations of polymorphisms of lipopolysaccharide binding protein （LBP）, cluster of differentiation 14 （CD14）, toll-like receptor 4 （TLR-4）, interleukin-6 （IL-6） and tumor necrosis factor α （TNF-α） with the colorectal carcinoma （CRC） risk in Han Chinese. METHODS： Polymorphisms of LBP （rs1739654, rs223 2596, rs2232618）, CD14 （rs77083413, rs4914）, TLR-4 （rs5030719）, IL-6 （rs13306435） and TNF-α （rs35131721） were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms （SNPs） between cases and controls were analyzed by unconditional logistic regression. RESULTS： GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk ofCRC [odds ratio （OR） = 1.51, 95% confidence interval （CI） 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 （OR= 1.69, 95% CI 1.20-2.36, P = 0.002）. In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC （OR = 3.44, 95% CI 1.94-6.10, P = 0.000）. CONCLUSION： This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.</description><subject>Acute-Phase Proteins - genetics</subject><subject>Adult</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Carrier Proteins - genetics</subject><subject>Case-Control Studies</subject><subject>CD14</subject><subject>Colorectal Neoplasms - genetics</subject><subject>DNA Primers - chemistry</subject><subject>Female</subject><subject>Humans</subject><subject>LBP</subject><subject>Lipopolysaccharide Receptors - genetics</subject><subject>logistic回归分析</subject><subject>Male</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Toll样受体4</subject><subject>中国汉族人群</subject><subject>基因多态性</subject><subject>大肠癌</subject><subject>风险</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUFvGyEQRlHVqHHc3nuq6CmndQZYG7hUSpy0jmQpOaS3SghY1ku6Cw6sE-XfhyiulZ4Yad58wDyEvhKYMV6Ls6f7zeyR8JknYkYZXXxAE0qJrKio4SOaEABeSUb5MTrJ-R6AMjann9AxJYtSSTFBf9YXt1iHBi8vSY23sX8eYtp2Pg8Z25iS6_Xo8JMfO-yDTU5n15RGH5Ozo-6x1cn6EAeNk89_C4NXOuBl54PL7jM6anWf3Zf9OUW_f17dLVfV-ubX9fJ8XdmakrGyfG6INVADs1qaRgrWLowRZEEabRvCGiNpQwUYbmndWuHmLScSBBflQ4awKfrxlrvdmcE11oUx6V5tkx90elZRe_V_J_hObeKjYiDLpqAEnO4DUnzYuTyqwWfr-l4HF3dZCQ5U1gLqQsIbaVPMObn2cAsB9epEFSeqOFHFiXp1Uka-vX_dYeCfhAJ832d2MWwefNgcGCaA0Tnj7AX6ApWf</recordid><startdate>20110514</startdate><enddate>20110514</enddate><creator>Chen, Rui</creator><creator>Luo, Fu-Kang</creator><creator>Wang, Ya-Li</creator><creator>Tang, Jin-Liang</creator><creator>Liu, You-Sheng</creator><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110514</creationdate><title>LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese</title><author>Chen, Rui ; Luo, Fu-Kang ; Wang, Ya-Li ; Tang, Jin-Liang ; Liu, You-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-c75b1cb0403ca9bd983f6bb8161dacd13db92d280b7c24fc8e5f7190878233b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute-Phase Proteins - genetics</topic><topic>Adult</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Carrier Proteins - genetics</topic><topic>Case-Control Studies</topic><topic>CD14</topic><topic>Colorectal Neoplasms - genetics</topic><topic>DNA Primers - chemistry</topic><topic>Female</topic><topic>Humans</topic><topic>LBP</topic><topic>Lipopolysaccharide Receptors - genetics</topic><topic>logistic回归分析</topic><topic>Male</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Toll样受体4</topic><topic>中国汉族人群</topic><topic>基因多态性</topic><topic>大肠癌</topic><topic>风险</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Rui</creatorcontrib><creatorcontrib>Luo, Fu-Kang</creatorcontrib><creatorcontrib>Wang, Ya-Li</creatorcontrib><creatorcontrib>Tang, Jin-Liang</creatorcontrib><creatorcontrib>Liu, You-Sheng</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Rui</au><au>Luo, Fu-Kang</au><au>Wang, Ya-Li</au><au>Tang, Jin-Liang</au><au>Liu, You-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2011-05-14</date><risdate>2011</risdate><volume>17</volume><issue>18</issue><spage>2326</spage><epage>2331</epage><pages>2326-2331</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To explore the associations of polymorphisms of lipopolysaccharide binding protein （LBP）, cluster of differentiation 14 （CD14）, toll-like receptor 4 （TLR-4）, interleukin-6 （IL-6） and tumor necrosis factor α （TNF-α） with the colorectal carcinoma （CRC） risk in Han Chinese. METHODS： Polymorphisms of LBP （rs1739654, rs223 2596, rs2232618）, CD14 （rs77083413, rs4914）, TLR-4 （rs5030719）, IL-6 （rs13306435） and TNF-α （rs35131721） were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms （SNPs） between cases and controls were analyzed by unconditional logistic regression. RESULTS： GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk ofCRC [odds ratio （OR） = 1.51, 95% confidence interval （CI） 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 （OR= 1.69, 95% CI 1.20-2.36, P = 0.002）. In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC （OR = 3.44, 95% CI 1.94-6.10, P = 0.000）. CONCLUSION： This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Co., Limited</pub><pmid>21633598</pmid><doi>10.3748/wjg.v17.i18.2326</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute-Phase Proteins - genetics Adult Aged Asian Continental Ancestry Group - genetics Carrier Proteins - genetics Case-Control Studies CD14 Colorectal Neoplasms - genetics DNA Primers - chemistry Female Humans LBP Lipopolysaccharide Receptors - genetics logistic回归分析 Male Membrane Glycoproteins - genetics Middle Aged Original Polymorphism, Single Nucleotide Risk Factors Toll样受体4 中国汉族人群 基因多态性 大肠癌 风险 |
| title | LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese |
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