LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese

AIM： To explore the associations of polymorphisms of lipopolysaccharide binding protein （LBP）, cluster of differentiation 14 （CD14）, toll-like receptor 4 （TLR-4）, interleukin-6 （IL-6） and tumor necrosis factor α （TNF-α） with the colorectal carcinoma （CRC） risk in Han Chinese. METHODS： Polymorphisms of LBP （rs1739654, rs223 2596, rs2232618）, CD14 （rs77083413, rs4914）, TLR-4 （rs5030719）, IL-6 （rs13306435） and TNF-α （rs35131721） were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms （SNPs） between cases and controls were analyzed by unconditional logistic regression. RESULTS： GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk ofCRC [odds ratio （OR） = 1.51, 95% confidence interval （CI） 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 （OR= 1.69, 95% CI 1.20-2.36, P = 0.002）. In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC （OR = 3.44, 95% CI 1.94-6.10, P = 0.000）. CONCLUSION： This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.