Ventilator-Associated Tracheitis in Children: Does Antibiotic Duration Matter?

Ventilator-Associated Tracheitis in Children: Does Antibiotic Duration Matter?

Background. The optimal duration of antibiotic therapy for ventilator-associated tracheitis (VAT) has not been defined, which may result in unnecessarily prolonged courses of antibiotics. The primary objective of this study was to determine whether prolonged-course (≥7 days in duration) therapy for...

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Veröffentlicht in:Clinical infectious diseases 2011-06, Vol.52 (11), p.1324-1331
Hauptverfasser: Tamma, Pranita D., Turnbull, Alison E., Milstone, Aaron M., Lehmann, Christoph U., Sydnor, Emily R. M., Cosgrove, Sara E.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
and Commentaries
Anti-Bacterial Agents - administration & dosage
Antibacterial agents
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
ARTICLES AND COMMENTARIES
Biological and medical sciences
Child
Child, Preschool
Children
Children & youth
Cohort Studies
Cross Infection - epidemiology
Cross Infection - prevention & control
Drug resistance
Female
General aspects
Health outcomes
Human infectious diseases. Experimental studies and models
Humans
Infant
Infections
Infectious diseases
Intensive care
Intensive Care Units
Male
Medical sciences
Neonatal intensive care units
Pediatric intensive care units
Pediatrics
Pharmacology. Drug treatments
Pneumonia
Pneumonia, Ventilator-Associated - epidemiology
Pneumonia, Ventilator-Associated - prevention & control
Respiration, Artificial - adverse effects
Retrospective Studies
Risk assessment
Throat
Time Factors
Tracheitis
Tracheitis - epidemiology
Ventilator associated pneumonia
Ventilators
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Zusammenfassung:Background. The optimal duration of antibiotic therapy for ventilator-associated tracheitis (VAT) has not been defined, which may result in unnecessarily prolonged courses of antibiotics. The primary objective of this study was to determine whether prolonged-course (≥7 days in duration) therapy for VAT was more protective against progression to hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP), compared with short-course antibiotics (
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cir203