A di-leucine sequence and a cluster of acidic amino acids are required for dynamic retention in the endosomal recycling compartment of fibroblasts

Insulin-regulated aminopeptidase (IRAP), a transmembrane aminopeptidase, is dynamically retained within the endosomal compartment of fibroblasts. The characteristics of this dynamic retention are rapid internalization from the plasma membrane and slow recycling back to the cell surface. These specia...

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Veröffentlicht in:	Molecular biology of the cell 2001-02, Vol.12 (2), p.367-381
Hauptverfasser:	Johnson, A O, Lampson, M A, McGraw, T E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Aminopeptidases - genetics Aminopeptidases - metabolism Animals Cell Compartmentation CHO Cells Cricetinae Cystinyl Aminopeptidase Endosomes - metabolism Fibroblasts - metabolism Genes, Reporter Leucine Molecular Sequence Data Mutation Receptors, Transferrin - genetics Receptors, Transferrin - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism
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Zusammenfassung:	Insulin-regulated aminopeptidase (IRAP), a transmembrane aminopeptidase, is dynamically retained within the endosomal compartment of fibroblasts. The characteristics of this dynamic retention are rapid internalization from the plasma membrane and slow recycling back to the cell surface. These specialized trafficking kinetics result in
ISSN:	1059-1524 1939-4586
DOI:	10.1091/mbc.12.2.367