Efficacy and complications of neurosurgical treatment of acromegaly
The aim of the study was to evaluate the frequency of occurrence of pituitary failure following neurosurgery and the efficacy of transsphenoidal tumour resection in acromegalic patients. We retrospectively evaluated 85 patients (60 female and 25 male), of mean age 43.9 ± 13.2 years, treated by trans...
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| Veröffentlicht in: | Pituitary 2011-06, Vol.14 (2), p.157-162 |
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| creator | Krzentowska-Korek, Anna Gołkowski, Filip Bałdys-Waligórska, Agata Hubalewska-Dydejczyk, Alicja |
| description | The aim of the study was to evaluate the frequency of occurrence of pituitary failure following neurosurgery and the efficacy of transsphenoidal tumour resection in acromegalic patients. We retrospectively evaluated 85 patients (60 female and 25 male), of mean age 43.9 ± 13.2 years, treated by transsphenoidal neurosurgery. Macroadenoma and microadenoma of pituitary were found in 66 (77.6%) and 19 (22.4%) of these patients, respectively. Criteria of cure following neurosurgery were: basal GH |
| doi_str_mv | 10.1007/s11102-010-0273-0 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3094540</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>876230123</sourcerecordid><originalsourceid>FETCH-LOGICAL-c566t-8352f287c62b51a2c7120f0966da5a856ac076d5ed77153ec60f8dbf5d3f42653</originalsourceid><addsrcrecordid>eNqFkU1LxDAQhoMofqz-AC9SvHiqTpIm6V4EWdYPELwoeAvZNFkrbbMmrbD_3lnWbxBPmWSeeWcyLyGHFE4pgDpLlFJgOVDIgSmewwbZpQIDVQDfxJiXMucFfdwheyk9A4LAi22yw7BOKT7eJZOp97U1dpmZrspsaBcNXvs6dCkLPuvcEEMa4hwfm6yPzvSt6_pVytgYWjc3zXKfbHnTJHfwfo7Iw-X0fnKd395d3UwubnMrpOzzkgvmWamsZDNBDbOKMvAwlrIywpRCGgtKVsJVSlHBnZXgy2rmRcV9waTgI3K-1l0Ms9ZVFgeJptGLWLcmLnUwtf6Z6eonPQ-vmsO4ELiSETl5F4jhZXCp122drGsa07kwJF0qyThQxv8npeKsGHOJ5PEv8jkMscM9ICSxqeAKIbqGcGcpRec_h6agV1bqtZUaHdIrK_Vq2KPvv_2s-PAOAbYGEqa6uYtfnf9WfQPVoaks</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>866403537</pqid></control><display><type>article</type><title>Efficacy and complications of neurosurgical treatment of acromegaly</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Krzentowska-Korek, Anna ; Gołkowski, Filip ; Bałdys-Waligórska, Agata ; Hubalewska-Dydejczyk, Alicja</creator><creatorcontrib>Krzentowska-Korek, Anna ; Gołkowski, Filip ; Bałdys-Waligórska, Agata ; Hubalewska-Dydejczyk, Alicja</creatorcontrib><description><![CDATA[The aim of the study was to evaluate the frequency of occurrence of pituitary failure following neurosurgery and the efficacy of transsphenoidal tumour resection in acromegalic patients. We retrospectively evaluated 85 patients (60 female and 25 male), of mean age 43.9 ± 13.2 years, treated by transsphenoidal neurosurgery. Macroadenoma and microadenoma of pituitary were found in 66 (77.6%) and 19 (22.4%) of these patients, respectively. Criteria of cure following neurosurgery were: basal GH < 2.5 μg/l, GH at 120 min in OGTT < 1.0 μg/l and serum concentration of IGF-1 within normal ranges for age and sex. After surgery 32 patients (37.6%) were cured and 53 patients (62.4%) required somatostatin analogue treatment. In patients cured by surgery, lower levels of basal GH (
P
< 0.05), IGF-1 (
P
< 0.001), GH at 120 min in OGTT and smaller size of pituitary tumour (
P
< 0.05) were found at diagnosis, as compared to patients in whom surgery was unsuccessful. Significant correlation between basal serum level of GH at diagnosis and size of pituitary tumour was found (
P
< 0.001). Invasive tumours were found in 45 of 53 (84.9%) patients not cured and in only 8 of 32 (25.0%) patients cured (
P
< 0.001). Impaired function of pituitary anterior lobe after surgery was observed in 30% and 4% of patients with macro- and microadenoma, respectively (
P
< 0.05). The efficacy of neurosurgery is affected by concentration of basal serum GH and IGF-1, GH at 120 min in OGTT, tumour size and invasiveness. Hypopituitarism after surgery is more frequent in patients with macroadenoma. Pituitary insufficiency, as a consequence of surgery, was found in 21% of patients with normal pituitary function prior to operation.]]></description><identifier>ISSN: 1386-341X</identifier><identifier>EISSN: 1573-7403</identifier><identifier>DOI: 10.1007/s11102-010-0273-0</identifier><identifier>PMID: 21107739</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acromegaly - blood ; Acromegaly - epidemiology ; Acromegaly - etiology ; Acromegaly - surgery ; Adenoma - complications ; Adenoma - epidemiology ; Adenoma - pathology ; Adenoma - surgery ; Adult ; Endocrinology ; Female ; Growth Hormone-Secreting Pituitary Adenoma - complications ; Growth Hormone-Secreting Pituitary Adenoma - epidemiology ; Growth Hormone-Secreting Pituitary Adenoma - pathology ; Growth Hormone-Secreting Pituitary Adenoma - surgery ; Human Growth Hormone - blood ; Human Physiology ; Humans ; Insulin-Like Growth Factor I - analysis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurosurgical Procedures - adverse effects ; Neurosurgical Procedures - rehabilitation ; Neurosurgical Procedures - statistics & numerical data ; Postoperative Complications - epidemiology ; Retrospective Studies ; Treatment Outcome ; Tumor Burden</subject><ispartof>Pituitary, 2011-06, Vol.14 (2), p.157-162</ispartof><rights>The Author(s) 2010</rights><rights>The Author(s) 2010. This article is published with open access at Springerlink.com</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-8352f287c62b51a2c7120f0966da5a856ac076d5ed77153ec60f8dbf5d3f42653</citedby><cites>FETCH-LOGICAL-c566t-8352f287c62b51a2c7120f0966da5a856ac076d5ed77153ec60f8dbf5d3f42653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11102-010-0273-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11102-010-0273-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21107739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krzentowska-Korek, Anna</creatorcontrib><creatorcontrib>Gołkowski, Filip</creatorcontrib><creatorcontrib>Bałdys-Waligórska, Agata</creatorcontrib><creatorcontrib>Hubalewska-Dydejczyk, Alicja</creatorcontrib><title>Efficacy and complications of neurosurgical treatment of acromegaly</title><title>Pituitary</title><addtitle>Pituitary</addtitle><addtitle>Pituitary</addtitle><description><![CDATA[The aim of the study was to evaluate the frequency of occurrence of pituitary failure following neurosurgery and the efficacy of transsphenoidal tumour resection in acromegalic patients. We retrospectively evaluated 85 patients (60 female and 25 male), of mean age 43.9 ± 13.2 years, treated by transsphenoidal neurosurgery. Macroadenoma and microadenoma of pituitary were found in 66 (77.6%) and 19 (22.4%) of these patients, respectively. Criteria of cure following neurosurgery were: basal GH < 2.5 μg/l, GH at 120 min in OGTT < 1.0 μg/l and serum concentration of IGF-1 within normal ranges for age and sex. After surgery 32 patients (37.6%) were cured and 53 patients (62.4%) required somatostatin analogue treatment. In patients cured by surgery, lower levels of basal GH (
P
< 0.05), IGF-1 (
P
< 0.001), GH at 120 min in OGTT and smaller size of pituitary tumour (
P
< 0.05) were found at diagnosis, as compared to patients in whom surgery was unsuccessful. Significant correlation between basal serum level of GH at diagnosis and size of pituitary tumour was found (
P
< 0.001). Invasive tumours were found in 45 of 53 (84.9%) patients not cured and in only 8 of 32 (25.0%) patients cured (
P
< 0.001). Impaired function of pituitary anterior lobe after surgery was observed in 30% and 4% of patients with macro- and microadenoma, respectively (
P
< 0.05). The efficacy of neurosurgery is affected by concentration of basal serum GH and IGF-1, GH at 120 min in OGTT, tumour size and invasiveness. Hypopituitarism after surgery is more frequent in patients with macroadenoma. Pituitary insufficiency, as a consequence of surgery, was found in 21% of patients with normal pituitary function prior to operation.]]></description><subject>Acromegaly - blood</subject><subject>Acromegaly - epidemiology</subject><subject>Acromegaly - etiology</subject><subject>Acromegaly - surgery</subject><subject>Adenoma - complications</subject><subject>Adenoma - epidemiology</subject><subject>Adenoma - pathology</subject><subject>Adenoma - surgery</subject><subject>Adult</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Growth Hormone-Secreting Pituitary Adenoma - complications</subject><subject>Growth Hormone-Secreting Pituitary Adenoma - epidemiology</subject><subject>Growth Hormone-Secreting Pituitary Adenoma - pathology</subject><subject>Growth Hormone-Secreting Pituitary Adenoma - surgery</subject><subject>Human Growth Hormone - blood</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurosurgical Procedures - adverse effects</subject><subject>Neurosurgical Procedures - rehabilitation</subject><subject>Neurosurgical Procedures - statistics & numerical data</subject><subject>Postoperative Complications - epidemiology</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Tumor Burden</subject><issn>1386-341X</issn><issn>1573-7403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkU1LxDAQhoMofqz-AC9SvHiqTpIm6V4EWdYPELwoeAvZNFkrbbMmrbD_3lnWbxBPmWSeeWcyLyGHFE4pgDpLlFJgOVDIgSmewwbZpQIDVQDfxJiXMucFfdwheyk9A4LAi22yw7BOKT7eJZOp97U1dpmZrspsaBcNXvs6dCkLPuvcEEMa4hwfm6yPzvSt6_pVytgYWjc3zXKfbHnTJHfwfo7Iw-X0fnKd395d3UwubnMrpOzzkgvmWamsZDNBDbOKMvAwlrIywpRCGgtKVsJVSlHBnZXgy2rmRcV9waTgI3K-1l0Ms9ZVFgeJptGLWLcmLnUwtf6Z6eonPQ-vmsO4ELiSETl5F4jhZXCp122drGsa07kwJF0qyThQxv8npeKsGHOJ5PEv8jkMscM9ICSxqeAKIbqGcGcpRec_h6agV1bqtZUaHdIrK_Vq2KPvv_2s-PAOAbYGEqa6uYtfnf9WfQPVoaks</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Krzentowska-Korek, Anna</creator><creator>Gołkowski, Filip</creator><creator>Bałdys-Waligórska, Agata</creator><creator>Hubalewska-Dydejczyk, Alicja</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110601</creationdate><title>Efficacy and complications of neurosurgical treatment of acromegaly</title><author>Krzentowska-Korek, Anna ; Gołkowski, Filip ; Bałdys-Waligórska, Agata ; Hubalewska-Dydejczyk, Alicja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-8352f287c62b51a2c7120f0966da5a856ac076d5ed77153ec60f8dbf5d3f42653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acromegaly - blood</topic><topic>Acromegaly - epidemiology</topic><topic>Acromegaly - etiology</topic><topic>Acromegaly - surgery</topic><topic>Adenoma - complications</topic><topic>Adenoma - epidemiology</topic><topic>Adenoma - pathology</topic><topic>Adenoma - surgery</topic><topic>Adult</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Growth Hormone-Secreting Pituitary Adenoma - complications</topic><topic>Growth Hormone-Secreting Pituitary Adenoma - epidemiology</topic><topic>Growth Hormone-Secreting Pituitary Adenoma - pathology</topic><topic>Growth Hormone-Secreting Pituitary Adenoma - surgery</topic><topic>Human Growth Hormone - blood</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurosurgical Procedures - adverse effects</topic><topic>Neurosurgical Procedures - rehabilitation</topic><topic>Neurosurgical Procedures - statistics & numerical data</topic><topic>Postoperative Complications - epidemiology</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Tumor Burden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krzentowska-Korek, Anna</creatorcontrib><creatorcontrib>Gołkowski, Filip</creatorcontrib><creatorcontrib>Bałdys-Waligórska, Agata</creatorcontrib><creatorcontrib>Hubalewska-Dydejczyk, Alicja</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pituitary</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krzentowska-Korek, Anna</au><au>Gołkowski, Filip</au><au>Bałdys-Waligórska, Agata</au><au>Hubalewska-Dydejczyk, Alicja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and complications of neurosurgical treatment of acromegaly</atitle><jtitle>Pituitary</jtitle><stitle>Pituitary</stitle><addtitle>Pituitary</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>14</volume><issue>2</issue><spage>157</spage><epage>162</epage><pages>157-162</pages><issn>1386-341X</issn><eissn>1573-7403</eissn><abstract><![CDATA[The aim of the study was to evaluate the frequency of occurrence of pituitary failure following neurosurgery and the efficacy of transsphenoidal tumour resection in acromegalic patients. We retrospectively evaluated 85 patients (60 female and 25 male), of mean age 43.9 ± 13.2 years, treated by transsphenoidal neurosurgery. Macroadenoma and microadenoma of pituitary were found in 66 (77.6%) and 19 (22.4%) of these patients, respectively. Criteria of cure following neurosurgery were: basal GH < 2.5 μg/l, GH at 120 min in OGTT < 1.0 μg/l and serum concentration of IGF-1 within normal ranges for age and sex. After surgery 32 patients (37.6%) were cured and 53 patients (62.4%) required somatostatin analogue treatment. In patients cured by surgery, lower levels of basal GH (
P
< 0.05), IGF-1 (
P
< 0.001), GH at 120 min in OGTT and smaller size of pituitary tumour (
P
< 0.05) were found at diagnosis, as compared to patients in whom surgery was unsuccessful. Significant correlation between basal serum level of GH at diagnosis and size of pituitary tumour was found (
P
< 0.001). Invasive tumours were found in 45 of 53 (84.9%) patients not cured and in only 8 of 32 (25.0%) patients cured (
P
< 0.001). Impaired function of pituitary anterior lobe after surgery was observed in 30% and 4% of patients with macro- and microadenoma, respectively (
P
< 0.05). The efficacy of neurosurgery is affected by concentration of basal serum GH and IGF-1, GH at 120 min in OGTT, tumour size and invasiveness. Hypopituitarism after surgery is more frequent in patients with macroadenoma. Pituitary insufficiency, as a consequence of surgery, was found in 21% of patients with normal pituitary function prior to operation.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>21107739</pmid><doi>10.1007/s11102-010-0273-0</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acromegaly - blood Acromegaly - epidemiology Acromegaly - etiology Acromegaly - surgery Adenoma - complications Adenoma - epidemiology Adenoma - pathology Adenoma - surgery Adult Endocrinology Female Growth Hormone-Secreting Pituitary Adenoma - complications Growth Hormone-Secreting Pituitary Adenoma - epidemiology Growth Hormone-Secreting Pituitary Adenoma - pathology Growth Hormone-Secreting Pituitary Adenoma - surgery Human Growth Hormone - blood Human Physiology Humans Insulin-Like Growth Factor I - analysis Male Medicine Medicine & Public Health Middle Aged Neurosurgical Procedures - adverse effects Neurosurgical Procedures - rehabilitation Neurosurgical Procedures - statistics & numerical data Postoperative Complications - epidemiology Retrospective Studies Treatment Outcome Tumor Burden |
| title | Efficacy and complications of neurosurgical treatment of acromegaly |
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