Room Temperature Aryl Trifluoromethylation via Copper-Mediated Oxidative Cross-Coupling

Room Temperature Aryl Trifluoromethylation via Copper-Mediated Oxidative Cross-Coupling

A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1−4 h. Proceeding under mild conditions, the method tolerates a range of functional...

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Veröffentlicht in:Journal of organic chemistry 2011-02, Vol.76 (4), p.1174-1176
Hauptverfasser: Senecal, Todd D, Parsons, Andrew T, Buchwald, Stephen L
Format: Artikel
Sprache:eng
Schlagworte:
Boronic Acids - chemistry
Catalysis
Chemistry
Copper - chemistry
Exact sciences and technology
Hydrocarbons, Fluorinated - chemistry
Methylation
Molecular Structure
Noncondensed benzenic compounds
Organic chemistry
Oxidative Coupling
Preparations and properties
Temperature
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Zusammenfassung:A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1−4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo1023377