SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF

In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase SIRT3 leads to metabolic reprogramming toward glycolysis. This shift is mediated by an increase in cellular reactive oxygen species (ROS) generation that amplifies HIF-α stabilization and HIF-dependent...

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Veröffentlicht in:	Cancer cell 2011-03, Vol.19 (3), p.299-300
1. Verfasser:	Schumacker, Paul T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cells, Cultured Fibroblasts - cytology Fibroblasts - metabolism Glucose - metabolism Glycolysis Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Metabolomics - methods Mice Mice, Knockout Models, Biological Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Reactive Oxygen Species - metabolism Sirtuin 3 - genetics Sirtuin 3 - metabolism
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Beschreibung
Zusammenfassung:	In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase SIRT3 leads to metabolic reprogramming toward glycolysis. This shift is mediated by an increase in cellular reactive oxygen species (ROS) generation that amplifies HIF-α stabilization and HIF-dependent gene expression, thereby driving the tumor phenotype.
ISSN:	1535-6108 1878-3686
DOI:	10.1016/j.ccr.2011.03.001