Fast voice-coil scanning optical-resolution photoacoustic microscopy

We developed a photoacoustic imaging system that has real-time imaging capability with optical resolution. The imaging system is capable of scanning at 20 Hz over a 9 mm range and up to 40 Hz over a 1 mm scanning range. A focused laser beam provides a lateral resolution of 3.4 μm as measured in an o...

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Veröffentlicht in:	Optics letters 2011-01, Vol.36 (2), p.139-141
Hauptverfasser:	LIDAI WANG, MASLOV, Konstantin, JUNJIE YAO, BIN RAO, WANG, Lihong V
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustics - instrumentation Animals Capillaries - cytology Cell Movement Chemical lasers Ear - blood supply Erythrocytes - cytology Exact sciences and technology Fundamental areas of phenomenology (including applications) Lasers Mice Microscopy - instrumentation Optical Phenomena Optics Physics Time Factors Tomography - instrumentation
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Beschreibung
Zusammenfassung:	We developed a photoacoustic imaging system that has real-time imaging capability with optical resolution. The imaging system is capable of scanning at 20 Hz over a 9 mm range and up to 40 Hz over a 1 mm scanning range. A focused laser beam provides a lateral resolution of 3.4 μm as measured in an optically nonscattering medium. Flows of micrometer-sized carbon particles or whole blood in a silicone tube and individual red blood cells (RBCs) in mouse ear capillaries were also imaged in real time, demonstrating the capability to image highly dynamic processes in vivo at a micrometer-scale resolution.
ISSN:	0146-9592 1539-4794
DOI:	10.1364/ol.36.000139