c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase

The progression and negative outcome of a variety of human carcinomas are intimately associated with aberrant activity of the c-Met oncogene. The underlying cause of this dysregulation, however, remains a subject of discussion, as the majority of cancer patients do not present with activating mutati...

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Veröffentlicht in:	Oncogene 2011-04, Vol.30 (17), p.2003-2016
Hauptverfasser:	Szabo, R, Rasmussen, A L, Moyer, A B, Kosa, P, Schafer, J M, Molinolo, A A, Gutkind, J S, Bugge, T H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/395 631/80/86 692/699/67/1536 AKT protein Animals Apoptosis Biological and medical sciences c-Met protein Carcinogenesis Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell Biology Cell migration Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cellular biology Epigenetics Epithelial cells Epithelial Cells - enzymology Epithelial Cells - pathology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Neoplastic Gene mutations Genetic aspects Genetic transformation Growth factors Head & neck cancer Head and Neck Neoplasms - enzymology Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Health aspects Hepatocyte growth factor Hepatocyte Growth Factor - metabolism Human Genetics Humans Internal Medicine Keratinocytes Keratinocytes - enzymology Keratinocytes - metabolism Keratinocytes - pathology Medical sciences Medicine Medicine & Public Health Mice Molecular and cellular biology Oncology original-article Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Paracrine signalling Pathogenesis Physiological aspects Proteases Protein Precursors - metabolism Proteins Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-met - deficiency Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Rapamycin Risk factors Serine Endopeptidases - metabolism Serine proteinase Signal Transduction Squamous cell carcinoma TOR protein TOR Serine-Threonine Kinases - metabolism Tumors Up-Regulation
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