Effect of Argyreia speciosa root extract on cafeteria diet-induced obesity in rats
Objectives : To evaluate the antiobesity effects of the ethanolic extract of Argyreia speciosa roots in rats fed with a cafeteria diet (CD). Materials and Methods : Obesity was induced in albino rats by feeding them a CD daily for 42 days, in addition to a normal diet. Body weight and food intake wa...
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Veröffentlicht in: | Indian journal of pharmacology 2011-03, Vol.43 (2), p.163-167 |
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Sprache: | eng |
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Zusammenfassung: | Objectives : To evaluate the antiobesity effects of the ethanolic
extract of Argyreia speciosa roots in rats fed with a cafeteria diet
(CD). Materials and Methods : Obesity was induced in albino rats by
feeding them a CD daily for 42 days, in addition to a normal diet. Body
weight and food intake was measured initially and then every week
thereafter. On day 42, the serum biochemical parameters were estimated
and the animals were sacrificed with an overdose of ether. The, liver
and parametrial adipose tissues were removed and weighed immediately.
The liver triglyceride content was estimated. The influence of the
extract on the pancreatic lipase activity was also determined by
measuring the rate of release of oleic acid from triolein. Results :
The body weight at two-to-six weeks and the final parametrial adipose
tissue weights were significantly lowered (P < 0.01 and P < 0.05,
respectively) in rats fed with the CD with Argyreia speciosa extract
500 mg/kg/day as compared to the CD alone. The extract also
significantly reduced (P < 0.01) the serum contents of leptin, total
cholesterol, low density lipoprotein (LDL), and triglycerides, which
were elevated in rats fed with CD alone. In addition, the extract
inhibited the induction of fatty liver with the accumulation of hepatic
triglycerides. The extract also showed inhibition of pancreatic lipase
activity by using triolein as a substrate. Conclusions : The ethanolic
extract of Argyreia speciosa roots produces inhibitory effects on
cafeteria diet-induced obesity in rats. |
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ISSN: | 0253-7613 1998-3751 |
DOI: | 10.4103/0253-7613.77353 |