Major depressive disorder and immunity to varicella-zoster virus in the elderly

Research highlights ► Lower levels of varicella-zoster virus cell-mediated immunity (VZV-CMI) explain the increased risk and severity of herpes zoster. ► Increasing age lowers VZV-CMI and is associated with increased risk of herpes zoster. ► The occurrence of major depression in older adults further...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2011-05, Vol.25 (4), p.759-766
Hauptverfasser:	Irwin, Michael R, Levin, Myron J, Carrillo, Carmen, Olmstead, Richard, Lucko, Anne, Lang, Nancy, Caulfield, Michael J, Weinberg, Adriana, Chan, Ivan S.F, Clair, Jim, Smith, Jeff G, Marchese, R.D, Williams, Heather M, Beck, Danielle J, McCook, Patricia T, Johnson, Gary, Oxman, Michael N
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging - blood Aging - immunology Allergy and Immunology Analysis of Variance Antibodies, Viral - blood Antidepressive Agents - immunology Antidepressive Agents - therapeutic use Case-Control Studies Cell-mediated immunity Cohort Studies Cross-Sectional Studies Depressive Disorder, Major - blood Depressive Disorder, Major - drug therapy Depressive Disorder, Major - immunology Elderly Female Herpes zoster Herpes Zoster - immunology Herpes Zoster - psychology Herpesvirus 3, Human - immunology Human Humans Immunity, Cellular - drug effects Immunity, Cellular - immunology Infectious disease Major depression Male Matched-Pair Analysis Middle Aged Psychiatry Reference Values Risk Factors Stress Varicella-zoster virus
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Beschreibung
Zusammenfassung:	Research highlights ► Lower levels of varicella-zoster virus cell-mediated immunity (VZV-CMI) explain the increased risk and severity of herpes zoster. ► Increasing age lowers VZV-CMI and is associated with increased risk of herpes zoster. ► The occurrence of major depression in older adults further lowers VZV-CMI. ► Severity of depressive symptoms, along with increasing age, correlate with lower levels of VZV-CMI in depressed subjects. ► Depression, and its severity, may add to the risk of herpes zoster in older adults.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2011.02.001