Synthesis and in vivo Evaluation of N-[N-[(S)-1,3-Dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L-cysteine, [18F]DCFBC: a New Imaging Probe for Prostate Cancer
Previously we demonstrated successful imaging of xenografts that express the prostate-specific membrane antigen (PSMA) using small animal positron emission tomography (PET) and the radiolabeled PSMA inhibitor N -[ N -[( S )-1,3-dicarboxypropyl]carbamoyl]- S -[ 11 C]methyl- L -cysteine, [ 11 C]DCMC....
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| Veröffentlicht in: | Clinical cancer research 2008-05, Vol.14 (10), p.3036-3043 |
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| container_issue | 10 |
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| container_title | Clinical cancer research |
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| creator | Mease, Ronnie C. Dusich, Crystal L. Foss, Catherine A. Ravert, Hayden T. Dannals, Robert F. Seidel, Jurgen Prideaux, Andrew Fox, James J. Sgouros, George Kozikowski, Alan P. Pomper, Martin G. |
| description | Previously we demonstrated successful imaging of xenografts that express the prostate-specific membrane antigen (PSMA) using small animal positron emission tomography (PET) and the radiolabeled PSMA inhibitor
N
-[
N
-[(
S
)-1,3-dicarboxypropyl]carbamoyl]-
S
-[
11
C]methyl-
L
-cysteine, [
11
C]DCMC. Herein we extend that work by preparing and testing a PSMA inhibitor of the same class labeled with fluorine-18 to facilitate clinical use. |
| doi_str_mv | 10.1158/1078-0432.CCR-07-1517 |
| format | Article |
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-[
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S
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11
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| fulltext | fulltext |
| identifier | ISSN: 1078-0432 |
| ispartof | Clinical cancer research, 2008-05, Vol.14 (10), p.3036-3043 |
| issn | 1078-0432 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3078104 |
| source | American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| title | Synthesis and in vivo Evaluation of N-[N-[(S)-1,3-Dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L-cysteine, [18F]DCFBC: a New Imaging Probe for Prostate Cancer |
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