Synthesis and in vivo Evaluation of N-[N-[(S)-1,3-Dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L-cysteine, [18F]DCFBC: a New Imaging Probe for Prostate Cancer

Previously we demonstrated successful imaging of xenografts that express the prostate-specific membrane antigen (PSMA) using small animal positron emission tomography (PET) and the radiolabeled PSMA inhibitor N -[ N -[( S )-1,3-dicarboxypropyl]carbamoyl]- S -[ 11 C]methyl- L -cysteine, [ 11 C]DCMC. Herein we extend that work by preparing and testing a PSMA inhibitor of the same class labeled with fluorine-18 to facilitate clinical use.