Total Synthesis and Complete Structural Assignment of Thiocillin I

Total Synthesis and Complete Structural Assignment of Thiocillin I

The total synthesis of the thiopeptide antibiotic, thiocillin I, is described. This work unequivocally defines the full structure (constitution and configuration) of the natural product as 1.

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Veröffentlicht in:Journal of the American Chemical Society 2011-04, Vol.133 (15), p.5900-5904
Hauptverfasser: Aulakh, Virender S, Ciufolini, Marco A
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Molecular Structure
Peptides - chemical synthesis
Peptides - chemistry
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Beschreibung
Zusammenfassung:The total synthesis of the thiopeptide antibiotic, thiocillin I, is described. This work unequivocally defines the full structure (constitution and configuration) of the natural product as 1.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja110166x