Total synthesis and biological evaluation of marinopyrrole A and analogs

A five-step total synthesis of the antibiotic marinopyrrole A ( 1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogs whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.

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Bibliographische Detailangaben
Veröffentlicht in:	Tetrahedron letters 2011-04, Vol.52 (17), p.2041-2043
Hauptverfasser:	Nicolaou, K.C., Simmons, Nicholas L., Chen, Jason S., Haste, Nina M., Nizet, Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogs Antibacterial agents Antibacterial properties antibiotic resistance Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Atropisomers Biological Biological and medical sciences chemical reactions chemical structure Chemistry Clauson-Kaas reaction Exact sciences and technology General aspects Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Marine natural products Medical sciences methicillin Organic chemistry Pharmacology. Drug treatments Preparations and properties Staphylococcus aureus Synthesis (chemistry) Tetrahedrons Total synthesis
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Beschreibung
Zusammenfassung:	A five-step total synthesis of the antibiotic marinopyrrole A ( 1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogs whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2010.09.059