West Nile Virus RNA Not Detected in Urine of 40 People Tested 6 Years After Acute West Nile Virus Disease

West Nile virus (WNV) causes an acute infection that is usually cleared by an effective immune response after several days of viremia. However, a recent study detected WNV RNA in the urine of 5 of 25 persons (20%) tested several years after their initial acute WNV disease. We evaluated an establishe...

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Veröffentlicht in:	The Journal of infectious diseases 2011-02, Vol.203 (3), p.344-347
Hauptverfasser:	Gibney, Katherine B., Lanciotti, Robert S., Sejvar, James J., Nugent, C. Thomas, Linnen, Jeffrey M., Delorey, Mark J., Lehman, Jennifer A., Boswell, Erin N., Staples, J. Erin, Fischer, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute diseases Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Child Child, Preschool Female Fundamental and applied biological sciences. Psychology Humans Infant Infections Infectious diseases Major and Brief Reports Male Medical sciences Microbiology Middle Aged Miscellaneous Nervous system diseases Preventive medicine Reverse transcriptase polymerase chain reaction RNA RNA, Viral - genetics RNA, Viral - urine Specimens Urine Viral diseases Virology VIRUSES West Nile Fever - urine West Nile Fever - virology West Nile virus West Nile virus - genetics Young Adult
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Zusammenfassung:	West Nile virus (WNV) causes an acute infection that is usually cleared by an effective immune response after several days of viremia. However, a recent study detected WNV RNA in the urine of 5 of 25 persons (20%) tested several years after their initial acute WNV disease. We evaluated an established cohort of 40 persons >6 years after initial infection with WNV. Urine collected from all participants tested negative for WNV RNA by reverse-transcription polymerase chain reaction and transcription-mediated amplification. Prospective studies are needed to determine if and for how long WNV persists in urine following WNV disease.
ISSN:	0022-1899 1537-6613 0022-1899 1537-6613
DOI:	10.1093/infdis/jiq057