In Vitro Characterization of GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease with a Favorable Resistance Profile

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2011-04, Vol.55 (4), p.1366-1376
Hauptverfasser:	CALLEBAUT, Christian, STRAY, Kirsten, MULATO, Andrew, HATADA, Marcos, PRISKICH, Tina, PARKIN, Neil, SWAMINATHAN, Swami, LEE, William, HE, Gong-Xin, LIANHONG XU, CIHLAR, Tomas, TSAI, Luong, WILLIAMS, Matt, YANG, Zheng-Yu, CANNIZZARO, Carina, LEAVITT, Stephanie A, XIAOHONG LIU, KELLY WANG, MURRAY, Bernard P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents antiretroviral agents Antiviral Agents Biological and medical sciences Calorimetry CD4 antigen CD4-Positive T-Lymphocytes - drug effects Cells, Cultured Crystallography, X-Ray Cytotoxicity HEK293 Cells Hep G2 Cells HIV Protease HIV Protease - chemistry HIV Protease - metabolism HIV Protease Inhibitors HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacology HIV-1 - drug effects Human immunodeficiency virus 1 Humans Kinetics Liver Lymphocytes T Macrophages Medical sciences Metabolism Molecular Structure Organophosphonates Organophosphonates - chemistry Pharmacokinetics Pharmacology. Drug treatments Proteasome Endopeptidase Complex - metabolism Proteinase Ritonavir Serum proteins Thermodynamics
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Zusammenfassung:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.01183-10