ASARM peptides: PHEX-dependent and -independent regulation of serum phosphate

Increased acidic serine aspartate-rich MEPE-associated motif (ASARM) peptides cause mineralization defects in X-linked hypophosphatemic rickets mice (HYP) and "directly" inhibit renal phosphate uptake in vitro. However, ASARM peptides also bind to phosphate-regulating gene with homologies...

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Veröffentlicht in:	American Journal of Physiology - Renal Physiology 2011-03, Vol.300 (3), p.F783-F791
Hauptverfasser:	David, Valentin, Martin, Aline, Hedge, Anne-Marie, Drezner, Marc K, Rowe, Peter S N
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Aspartic Acid Chromosomes Correlation analysis Diet Extracellular Matrix Proteins - metabolism Extracellular Matrix Proteins - physiology Fibroblast Growth Factors - metabolism Glycoproteins - physiology Hormones Hypophosphatemia - metabolism Kidney - metabolism Male Mice Mice, Inbred C57BL Models, Animal Molecular Sequence Data Peptides Peptides - physiology PHEX Phosphate Regulating Neutral Endopeptidase - physiology Phosphates Phosphates - blood Phosphoproteins - physiology Rodents Serine Sodium-Phosphate Cotransporter Proteins, Type IIa - metabolism Vitamin D
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