Skin Intrinsic Fluorescence Correlates With Autonomic and Distal Symmetrical Polyneuropathy in Individuals With Type 1 Diabetes

OBJECTIVE: To determine whether skin intrinsic fluorescence (SIF) was associated with autonomic neuropathy and confirmed distal symmetrical polyneuropathy (CDSP) in 111 individuals with type 1 diabetes (mean age 49 years, mean diabetes duration 40 years). RESEARCH DESIGN AND METHODS: SIF was measure...

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Veröffentlicht in:	Diabetes care 2011-04, Vol.34 (4), p.1000-1005
Hauptverfasser:	Conway, Baqiyyah N, Aroda, Vanita R, Maynard, John D, Matter, Nathaniel, Fernandez, Stephen, Ratner, Robert E, Orchard, Trevor J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Area Under Curve Autonomic Nervous System - pathology breathing clinical trials Diabetes Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - physiopathology Diabetic Neuropathies - diagnosis Diabetic Neuropathies - metabolism Diabetic neuropathy Electrocardiography Epidemiology Female Fluorescence Glycated Hemoglobin A - metabolism glycation Glycation End Products, Advanced - metabolism heart rate Humans insulin-dependent diabetes mellitus Male Medical research Methods Middle Aged Multivariate Analysis Nitric oxide odds ratio Original Research Pathogenesis peripheral nervous system diseases Polyneuropathies Polyneuropathies - diagnosis Polyneuropathies - metabolism Skin Skin - metabolism Studies
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Zusammenfassung:	OBJECTIVE: To determine whether skin intrinsic fluorescence (SIF) was associated with autonomic neuropathy and confirmed distal symmetrical polyneuropathy (CDSP) in 111 individuals with type 1 diabetes (mean age 49 years, mean diabetes duration 40 years). RESEARCH DESIGN AND METHODS: SIF was measured using the SCOUT DM device. Autonomic neuropathy was defined as an electrocardiographic abnormal heart rate response to deep breathing (expiration-to-inspiration ratio
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc10-1791