The conformations of 17β-estradiol (E2) and 17α-estradiol as determined by solution NMR

The conformations of 17β-estradiol (E2) and 17α-estradiol as determined by solution NMR

The conformational structures of the hormone 17β-estradiol (E2) and the epimeric 17α-estradiol determined by solution NMR spectroscopy and restrained molecular dynamics calculations found a single low energy conformation.

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Veröffentlicht in:Tetrahedron letters 2010-07, Vol.51 (27), p.3465-3469
Hauptverfasser: Guo, Jianxin, Duclos, Richard I., Vemuri, V. Kiran, Makriyannis, Alexandros
Format: Artikel
Sprache:eng
Schlagworte:
17α-Estradiol
17β-Estradiol
Conformation
Molecular modeling
NMR
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Beschreibung
Zusammenfassung:The conformational structures of the hormone 17β-estradiol (E2) and the epimeric 17α-estradiol determined by solution NMR spectroscopy and restrained molecular dynamics calculations found a single low energy conformation.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.04.077