Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease

Cardiovascular diseases are the most common cause of death among the elderly in the Western world. Resveratrol (3,5,4′‐trihydroxystilbene) is a plant‐derived polyphenol that was shown to exert diverse anti‐aging activity mimicking some of the molecular and functional effects of caloric restriction....

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2011-01, Vol.1215 (1), p.117-122
1. Verfasser:	Csiszar, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - drug effects Aging - metabolism Aging - pathology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cardiovascular Diseases - prevention & control Humans Oxidative Stress - drug effects Oxidative Stress - physiology resveratrol Stilbenes - pharmacology Stilbenes - therapeutic use vascular dysfunction
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Beschreibung
Zusammenfassung:	Cardiovascular diseases are the most common cause of death among the elderly in the Western world. Resveratrol (3,5,4′‐trihydroxystilbene) is a plant‐derived polyphenol that was shown to exert diverse anti‐aging activity mimicking some of the molecular and functional effects of caloric restriction. This mini‐review focuses on the molecular and cellular mechanisms activated by resveratrol in the vascular system, and explores the links between its anti‐oxidative and anti‐inflammatory effects, which could be exploited for the prevention or amelioration of vascular aging in the elderly.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.2010.05848.x