Balancing Life and Death in the Ischemic Brain: SIK and TORC Weigh In

Balancing Life and Death in the Ischemic Brain: SIK and TORC Weigh In

Activation of NMDA receptors during cerebral ischemia triggers signaling pathways that promote both neuronal death and survival. In this issue of Neuron, Sasaki et al. present evidence for a new endogenous survival pathway involving the kinase SIK2 and the CREB coactivator TORC1. The powerful neurop...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2011-01, Vol.69 (1), p.3-6
Hauptverfasser: Gallo, Eduardo F., Iadecola, Costantino
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Brain
Gene expression
Ischemia
Kinases
Neurons
Phosphorylation
Rodents
Studies
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Zusammenfassung:Activation of NMDA receptors during cerebral ischemia triggers signaling pathways that promote both neuronal death and survival. In this issue of Neuron, Sasaki et al. present evidence for a new endogenous survival pathway involving the kinase SIK2 and the CREB coactivator TORC1. The powerful neuroprotection conferred by this pathway has considerable translational potential for stroke therapy.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2010.12.029