Gd-Labeled Microparticles in MRI: In vivo Imaging of Microparticles After Intraperitoneal Injection

Gd-Labeled Microparticles in MRI: In vivo Imaging of Microparticles After Intraperitoneal Injection

To visualize the biodistribution of porous silica microparticles in vivo, known ligands are used to immobilize gadolinium in the pores for use as MRI contrast agents. MRI studies with rodents show that a fraction of the microparticles administered by intraperitoneal injection passed through the kidn...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2010-12, Vol.6 (23), p.2678-2682
Hauptverfasser: Steinbacher, Jeremy L., Lathrop, Sherrill A., Cheng, Kai, Hillegass, Jedd M., Butnor, Kelly J., Kauppinen, Risto A., Mossman, Brooke T., Landry, Christopher C.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biomedical applications
Gadolinium DTPA
Injections, Intraperitoneal
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Mesoporous materials
Mice
Mice, Inbred C57BL
Particle excretion
Porosity
Silica
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:To visualize the biodistribution of porous silica microparticles in vivo, known ligands are used to immobilize gadolinium in the pores for use as MRI contrast agents. MRI studies with rodents show that a fraction of the microparticles administered by intraperitoneal injection passed through the kidneys by an unknown mechanism and are, surprisingly, excreted via the urine. Analysis of the urine with SEM and energy dispersive spectroscopy corroborated the MRI results.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201001447