Electrostatic Stabilization of a Native Protein Structure in the Gas Phase

One, two, three, whee! After transfer into the gas phase, the three‐helix bundle protein KIX is sufficiently stabilized by electrostatic interactions to compensate for the loss of hydrophobic bonding. It thus retains its global fold on a timescale of more than 4 s.

Bibliographische Detailangaben

Veröffentlicht in:	Angewandte Chemie (International ed.) 2011-01, Vol.50 (4), p.873-877
Hauptverfasser:	Breuker, Kathrin, Brüschweiler, Sven, Tollinger, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Communication electron capture dissociation electrostatic interactions gas phase Gases - chemistry Models, Molecular native mass spectrometry Protein Conformation protein structure Proteins - chemistry Static Electricity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!