Electrostatic Stabilization of a Native Protein Structure in the Gas Phase

Electrostatic Stabilization of a Native Protein Structure in the Gas Phase

One, two, three, whee! After transfer into the gas phase, the three‐helix bundle protein KIX is sufficiently stabilized by electrostatic interactions to compensate for the loss of hydrophobic bonding. It thus retains its global fold on a timescale of more than 4 s.

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Veröffentlicht in:Angewandte Chemie (International ed.) 2011-01, Vol.50 (4), p.873-877
Hauptverfasser: Breuker, Kathrin, Brüschweiler, Sven, Tollinger, Martin
Format: Artikel
Sprache:eng
Schlagworte:
Communication
electron capture dissociation
electrostatic interactions
gas phase
Gases - chemistry
Models, Molecular
native mass spectrometry
Protein Conformation
protein structure
Proteins - chemistry
Static Electricity
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Beschreibung
Zusammenfassung:One, two, three, whee! After transfer into the gas phase, the three‐helix bundle protein KIX is sufficiently stabilized by electrostatic interactions to compensate for the loss of hydrophobic bonding. It thus retains its global fold on a timescale of more than 4 s.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201005112