Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge
Abstract Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIVmac251 challenges, exhibited elite control of viremia over 6.5 years. They were negative for host factors associated with control of SIV infection. After a third intrarectal challenge with...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2011-03, Vol.411 (1), p.87-102 |
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| creator | Patterson, L. Jean Daltabuit-Test, Mara Xiao, Peng Zhao, Jun Hu, William Wille-Reece, Ulrike Brocca-Cofano, Egidio Kalyanaraman, V.S Kalisz, Irene Whitney, Stephen Lee, Eun Mi Pal, Ranajit Montefiori, David C Dandekar, Satya Seder, Robert Roederer, Mario Wiseman, Roger W Hirsch, Vanessa Robert-Guroff, Marjorie |
| description | Abstract Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIVmac251 challenges, exhibited elite control of viremia over 6.5 years. They were negative for host factors associated with control of SIV infection. After a third intrarectal challenge with SIVsmE660 , all controlled viremia, with one (macaque #5) maintaining undetectable viremia in blood. Acquisition was not blocked, but virus was contained in the jejunum and draining lymph nodes. Polyfunctional memory T cell responses and high-titered neutralizing and non-neutralizing serum and mucosal antibodies were present before and maintained post-challenge. The level of protection seen for animal #5 was predicted from analyses of gene transcription in jejunum 2 weeks post-challenge. Macaques #7 and #9, exhibiting lower pre-challenge cellular and humoral immunity, partially controlled the SIVsmE660 challenge. Initial vaccine-induced control by macaque #5 extended to the SIVsmE660 challenge due to multiple immune mechanisms that were boosted and augmented by cryptic SIV exposure. |
| doi_str_mv | 10.1016/j.virol.2010.12.033 |
| format | Article |
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Jean ; Daltabuit-Test, Mara ; Xiao, Peng ; Zhao, Jun ; Hu, William ; Wille-Reece, Ulrike ; Brocca-Cofano, Egidio ; Kalyanaraman, V.S ; Kalisz, Irene ; Whitney, Stephen ; Lee, Eun Mi ; Pal, Ranajit ; Montefiori, David C ; Dandekar, Satya ; Seder, Robert ; Roederer, Mario ; Wiseman, Roger W ; Hirsch, Vanessa ; Robert-Guroff, Marjorie</creator><creatorcontrib>Patterson, L. Jean ; Daltabuit-Test, Mara ; Xiao, Peng ; Zhao, Jun ; Hu, William ; Wille-Reece, Ulrike ; Brocca-Cofano, Egidio ; Kalyanaraman, V.S ; Kalisz, Irene ; Whitney, Stephen ; Lee, Eun Mi ; Pal, Ranajit ; Montefiori, David C ; Dandekar, Satya ; Seder, Robert ; Roederer, Mario ; Wiseman, Roger W ; Hirsch, Vanessa ; Robert-Guroff, Marjorie</creatorcontrib><description>Abstract Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIVmac251 challenges, exhibited elite control of viremia over 6.5 years. They were negative for host factors associated with control of SIV infection. After a third intrarectal challenge with SIVsmE660 , all controlled viremia, with one (macaque #5) maintaining undetectable viremia in blood. Acquisition was not blocked, but virus was contained in the jejunum and draining lymph nodes. Polyfunctional memory T cell responses and high-titered neutralizing and non-neutralizing serum and mucosal antibodies were present before and maintained post-challenge. The level of protection seen for animal #5 was predicted from analyses of gene transcription in jejunum 2 weeks post-challenge. Macaques #7 and #9, exhibiting lower pre-challenge cellular and humoral immunity, partially controlled the SIVsmE660 challenge. Initial vaccine-induced control by macaque #5 extended to the SIVsmE660 challenge due to multiple immune mechanisms that were boosted and augmented by cryptic SIV exposure.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2010.12.033</identifier><identifier>PMID: 21237474</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antibodies, Neutralizing - immunology ; Antibodies, Viral - immunology ; Elite-control ; Immunity, Cellular ; Immunity, Mucosal ; Infectious Disease ; Jejunum - virology ; Lymph Nodes - virology ; Macaca mulatta ; Memory ; Multifaceted immunity ; Serum - immunology ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Acquired Immunodeficiency Syndrome - prevention & control ; Simian immunodeficiency virus ; Simian Immunodeficiency Virus - immunology ; SIV ; T-Lymphocytes - immunology ; Vaccine ; Viremia - prevention & control ; Virus sequestration</subject><ispartof>Virology (New York, N.Y.), 2011-03, Vol.411 (1), p.87-102</ispartof><rights>2010</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-b23907d953865828c4b56076046ca008904ba543dc9cf3c039cfd687d789654a3</citedby><cites>FETCH-LOGICAL-c545t-b23907d953865828c4b56076046ca008904ba543dc9cf3c039cfd687d789654a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0042682210007907$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21237474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patterson, L. Jean</creatorcontrib><creatorcontrib>Daltabuit-Test, Mara</creatorcontrib><creatorcontrib>Xiao, Peng</creatorcontrib><creatorcontrib>Zhao, Jun</creatorcontrib><creatorcontrib>Hu, William</creatorcontrib><creatorcontrib>Wille-Reece, Ulrike</creatorcontrib><creatorcontrib>Brocca-Cofano, Egidio</creatorcontrib><creatorcontrib>Kalyanaraman, V.S</creatorcontrib><creatorcontrib>Kalisz, Irene</creatorcontrib><creatorcontrib>Whitney, Stephen</creatorcontrib><creatorcontrib>Lee, Eun Mi</creatorcontrib><creatorcontrib>Pal, Ranajit</creatorcontrib><creatorcontrib>Montefiori, David C</creatorcontrib><creatorcontrib>Dandekar, Satya</creatorcontrib><creatorcontrib>Seder, Robert</creatorcontrib><creatorcontrib>Roederer, Mario</creatorcontrib><creatorcontrib>Wiseman, Roger W</creatorcontrib><creatorcontrib>Hirsch, Vanessa</creatorcontrib><creatorcontrib>Robert-Guroff, Marjorie</creatorcontrib><title>Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>Abstract Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIVmac251 challenges, exhibited elite control of viremia over 6.5 years. 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Initial vaccine-induced control by macaque #5 extended to the SIVsmE660 challenge due to multiple immune mechanisms that were boosted and augmented by cryptic SIV exposure.</description><subject>Animals</subject><subject>Antibodies, Neutralizing - immunology</subject><subject>Antibodies, Viral - immunology</subject><subject>Elite-control</subject><subject>Immunity, Cellular</subject><subject>Immunity, Mucosal</subject><subject>Infectious Disease</subject><subject>Jejunum - virology</subject><subject>Lymph Nodes - virology</subject><subject>Macaca mulatta</subject><subject>Memory</subject><subject>Multifaceted immunity</subject><subject>Serum - immunology</subject><subject>Simian Acquired Immunodeficiency Syndrome - immunology</subject><subject>Simian Acquired Immunodeficiency Syndrome - prevention & control</subject><subject>Simian immunodeficiency virus</subject><subject>Simian Immunodeficiency Virus - immunology</subject><subject>SIV</subject><subject>T-Lymphocytes - immunology</subject><subject>Vaccine</subject><subject>Viremia - prevention & control</subject><subject>Virus sequestration</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsFu1DAQjRCIlsIXICHfuJDFjhMnOVCpqgpUqoREgavltWezXhx7sZ2Vlg_j-5h0lwq49DT2-L3xzLxXFC8ZXTDKxNvNYmdjcIuKzplqQTl_VJwy2ouS8po9Lk4pratSdFV1UjxLaUPx3rb0aXFSsYq3dVufFr8-q6015Pb6G7nyuzJtQduV1WScdEjKEeUNSRCnEU_ZLoPZE-vNpLMNnqhpGMHnRDQ4NzkViR3Hyds8g8g2hgwI9MMx_RPMGwLOZih18Bl7dxDJqLT6MUEialDWp0zWdlgTExKQNWRAVBjClO5a1GuFHD_A8-LJSrkEL47xrPj6_urL5cfy5tOH68uLm1I3dZPLZcV72pq-4Z1ouqrT9bIRtBW0FlpR2vW0Xqqm5kb3esU15RiM6FrTdr1oasXPivND3e20HMFonDYqJ7fRjiruZVBW_vvi7VoOYSc51qKCYoHXxwIxzFNmOdo0r0t5wKlkJ_qmQzW7h5ENQ8l42yOSH5A6hpQirO77YVTO1pAbeWcNOVtDskqiNZD16u9R7jl_vICAdwcA4EJ3FqJM2oLXYGxEHaUJ9oEPzv_ja2e91cp9hz2kTZiiR60kkwkJ8nZ252xOhr5sUSb-GxNs5V8</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Patterson, L. 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Jean</au><au>Daltabuit-Test, Mara</au><au>Xiao, Peng</au><au>Zhao, Jun</au><au>Hu, William</au><au>Wille-Reece, Ulrike</au><au>Brocca-Cofano, Egidio</au><au>Kalyanaraman, V.S</au><au>Kalisz, Irene</au><au>Whitney, Stephen</au><au>Lee, Eun Mi</au><au>Pal, Ranajit</au><au>Montefiori, David C</au><au>Dandekar, Satya</au><au>Seder, Robert</au><au>Roederer, Mario</au><au>Wiseman, Roger W</au><au>Hirsch, Vanessa</au><au>Robert-Guroff, Marjorie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>411</volume><issue>1</issue><spage>87</spage><epage>102</epage><pages>87-102</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><abstract>Abstract Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIVmac251 challenges, exhibited elite control of viremia over 6.5 years. 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| subjects | Animals Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Elite-control Immunity, Cellular Immunity, Mucosal Infectious Disease Jejunum - virology Lymph Nodes - virology Macaca mulatta Memory Multifaceted immunity Serum - immunology Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian immunodeficiency virus Simian Immunodeficiency Virus - immunology SIV T-Lymphocytes - immunology Vaccine Viremia - prevention & control Virus sequestration |
| title | Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge |
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