Autoantibodies to cerebellum in children with autism associate with behavior

Research highlights ► Plasma autoantibodies for 45 kDa cerebellar protein associate with an autism diagnosis. ► Plasma autoantibodies for 62 kDa protein associate with broader diagnosis of ASD. ► Children with autoantibodies had worse behavioral scores than children without them. ► Few familial asso...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2011-03, Vol.25 (3), p.514-523
Hauptverfasser:	Goines, Paula, Haapanen, Lori, Boyce, Robert, Duncanson, Paul, Braunschweig, Daniel, Delwiche, Lora, Hansen, Robin, Hertz-Picciotto, Irva, Ashwood, Paul, Van de Water, Judy
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Autism spectrum disorders Autistic Disorder - immunology Autistic Disorder - metabolism Autoantibodies - blood Autoantibodies - immunology Autoantibody Behavior Blotting, Western Brain Cerebellum Cerebellum - immunology Cerebellum - metabolism Child Behavior - physiology Child, Preschool Cognition - physiology Fetal Proteins - immunology Fetal Proteins - metabolism Humans Immune system Immunoglobulin Neurodevelopment Psychiatry
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Beschreibung
Zusammenfassung:	Research highlights ► Plasma autoantibodies for 45 kDa cerebellar protein associate with an autism diagnosis. ► Plasma autoantibodies for 62 kDa protein associate with broader diagnosis of ASD. ► Children with autoantibodies had worse behavioral scores than children without them. ► Few familial associations found for brain-targeted antibodies in children and mothers. ► Antibodies may be markers for specific behavioral characteristics of autism.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2010.11.017