A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross-Coupling

A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross-Coupling

Not so complex: A novel iterative cross‐coupling strategy provides access to useful building blocks that enable the simple preparation of complex polyene natural‐product motifs in all possible stereoisomeric forms. The method was used to synthesize the polyene core of vacidin A (see structure)....

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Veröffentlicht in:Angewandte Chemie International Edition 2010-11, Vol.49 (47), p.8860-8863
Hauptverfasser: Lee, Suk Joong, Anderson, Thomas M., Burke, Martin D.
Format: Artikel
Sprache:eng
Schlagworte:
Boronic Acids - chemistry
Candicidin - analogs & derivatives
Candicidin - chemistry
Communications
haloboronic acids
Halogens - chemistry
Imino Acids - chemistry
iterative cross-coupling
MIDA boronates
polyenes
Polyenes - chemistry
Stereoisomerism
vacidin A
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Beschreibung
Zusammenfassung:Not so complex: A novel iterative cross‐coupling strategy provides access to useful building blocks that enable the simple preparation of complex polyene natural‐product motifs in all possible stereoisomeric forms. The method was used to synthesize the polyene core of vacidin A (see structure).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201004911