Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

Summary Background Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality. We...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Lancet (British edition) 2010-11, Vol.376 (9753), p.1647-1657
Hauptverfasser:	Dondorp, Arjen M, MD, Fanello, Caterina I, PhD, Hendriksen, Ilse CE, MD, Gomes, Ermelinda, MD, Seni, Amir, MD, Chhaganlal, Kajal D, MD, Bojang, Kalifa, FRCP, Olaosebikan, Rasaq, FWACP, Anunobi, Nkechinyere, FMCpaed, Maitland, Kathryn, Prof, Kivaya, Esther, MSc, Agbenyega, Tsiri, Prof, Nguah, Samuel Blay, FWACPCH, Evans, Jennifer, MRCPCH, Gesase, Samwel, MD, Kahabuka, Catherine, MD, Mtove, George, MD, Nadjm, Behzad, MD, Deen, Jacqueline, MD, Mwanga-Amumpaire, Juliet, MD, Nansumba, Margaret, MD, Karema, Corine, MD, Umulisa, Noella, MD, Uwimana, Aline, MD, Mokuolu, Olugbenga A, FWACP, Adedoyin, Olanrewaju T, FWACP, Johnson, Wahab BR, Prof, Tshefu, Antoinette K, Prof, Onyamboko, Marie A, MB, Sakulthaew, Tharisara, BNS, Ngum, Wirichada Pan, PhD, Silamut, Kamolrat, PhD, Stepniewska, Kasia, PhD, Woodrow, Charles J, MRCP, Bethell, Delia, MRCPCH, Wills, Bridget, FRCPCH, Oneko, Martina, MD, Peto, Tim E, Prof, von Seidlein, Lorenz, PhD, Day, Nicholas PJ, Prof, White, Nicholas J, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa South of the Sahara Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - adverse effects Antimalarials - therapeutic use Antiparasitic agents Artemisinins - adverse effects Artemisinins - therapeutic use Artesunate Biological and medical sciences Biomedical research Child, Preschool Fast track Female General aspects Hospitals Human protozoal diseases Humans Infant Infectious diseases Internal Medicine Kaplan-Meier Estimate Malaria Malaria, Falciparum - complications Malaria, Falciparum - drug therapy Malaria, Falciparum - mortality Male Medical research Medical sciences Medicine Mortality Parasitic diseases Pharmacology. Drug treatments Protozoal diseases Quinine - adverse effects Quinine - therapeutic use Survival Rate Systematic review Vector-borne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary Background Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality. We compared parenteral treatment with either artesunate or quinine in African children with severe malaria. Methods This open-label, randomised trial was undertaken in 11 centres in nine African countries. Children (
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(10)61924-1