Ht31, a Protein Kinase A Anchoring Inhibitor, Induces Robust Cholesterol Efflux and Reverses Macrophage Foam Cell Formation through ATP-binding Cassette Transporter A1

Macrophage foam cell is the predominant cell type in atherosclerotic lesions. Removal of excess cholesterol from macrophages thus offers effective protection against atherosclerosis. Here we report that a protein kinase A (PKA)-anchoring inhibitor, st-Ht31, induces robust cholesterol/phospholipid ef...

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Veröffentlicht in:	The Journal of biological chemistry 2011-02, Vol.286 (5), p.3370-3378
Hauptverfasser:	Ma, Loretta, Dong, Fumin, Denis, Maxime, Feng, Ying, Wang, Ming-Dong, Zha, Xiaohui
Format:	Artikel
Sprache:	eng
Schlagworte:	A-Kinase Anchoring Protein ABC Transporter ABCA1 ABCA1 protein Animals Arteriosclerosis ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - physiology ATP-binding protein Biological Transport - drug effects Biosensors Cell Line Cholesterol Cholesterol - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cytoplasm fluorescence resonance energy transfer Fluorescence Resonance Energy Transfer (FRET) Foam Cells - cytology Foam Cells - drug effects Inflammation Lipids Lipopolysaccharides Macrophage Macrophages Macrophages - cytology Mice Phospholipids Protein kinase A Protein Kinase A (PKA) Proteins - pharmacology Toxicity
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