Mystery of a giant leg

Klippel-Trenaunay-Weber syndrome is a combination of venous and capillary malformations associated with soft tissue and/or bony hypertrophy, with or without lymphatic malformations. 1 Typically, only one limb is involved, with the lower limbs representing 70% of cases. 2 The aetiology of this syndrome is unknown, but some authors have suggested that it results from a mesodermal abnormality that occurs during fetal development. 3 Bone hypertrophy usually results in limb length discrepancy.