Rapidly lethal metastatic melanoma arising from a large congenital melanocytic naevus

A case of fatal metastatic melanoma arising from a very large congenital melanocytic naevus (VLCMN) is reported. Large congenital naevi (LCMN) are naevi >20 cm in diameter. VLCMN is used in this report to mean an extensive LCMN involving a large percentage of the body, including smaller so-called...

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Veröffentlicht in:BMJ case reports 2009, Vol.2009 (feb26 1), p.bcr0920080981-bcr0920080981
Hauptverfasser: Wei, Christina Hsiao, Shoo, Brenda A, Zedek, Daniel C, Kashani-Sabet, Mohammed, Sagebiel, Richard W, Leong, Stanley P L
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Sprache:eng
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Zusammenfassung:A case of fatal metastatic melanoma arising from a very large congenital melanocytic naevus (VLCMN) is reported. Large congenital naevi (LCMN) are naevi >20 cm in diameter. VLCMN is used in this report to mean an extensive LCMN involving a large percentage of the body, including smaller so-called satellite naevi. A 19-year-old man with a large congenital melanocytic naevus (LCMN) presented with a new nodule on the left chest wall, which was diagnosed as a thick melanoma with synchronous axillary lymph-node metastasis. The patient developed widespread distant metastasis within weeks after surgical resection of the primary site and lymph-node basin, which was unresponsive to systemic chemotherapy and whole brain radiation therapy, and he died 7 months after diagnosis of the primary melanoma.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr.09.2008.0981