Yin Yang 1: A multifaceted protein beyond a transcription factor

As a transcription factor, Yin Yang 1 (YY1) regulates the transcription of a dazzling list of genes and the number of its targets still mounts. Recent studies revealed that YY1 possesses functions independent of its DNA binding activity and its regulatory role in tumorigenesis has started to emerge.

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Veröffentlicht in:	Transcription 2010-09, Vol.1 (2), p.81-84
Hauptverfasser:	Deng, Zhiyong, Cao, Paul, Wan, Mei Mei, Sui, Guangchao
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biology Bioscience Calcium Cancer Cell Cycle Gene Expression Regulation, Neoplastic Humans Landes Male Models, Genetic Organogenesis Point-of-View Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Proteins Trans-Activators - genetics Trans-Activators - metabolism Transcription, Genetic - genetics YY1 Transcription Factor - genetics YY1 Transcription Factor - metabolism
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Beschreibung
Zusammenfassung:	As a transcription factor, Yin Yang 1 (YY1) regulates the transcription of a dazzling list of genes and the number of its targets still mounts. Recent studies revealed that YY1 possesses functions independent of its DNA binding activity and its regulatory role in tumorigenesis has started to emerge.
ISSN:	2154-1264 2154-1272
DOI:	10.4161/trns.1.2.12375