miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1

Using RNA-seq technology, we found that the majority of microRNAs (miRNAs) present in CFU-E erythroid progenitors are down-regulated during terminal erythroid differentiation. Of the developmentally down-regulated miRNAs, ectopic overexpression of miR-191 blocks erythroid enucleation but has minor e...

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Veröffentlicht in:	Genes & development 2011-01, Vol.25 (2), p.119-124
Hauptverfasser:	Zhang, Lingbo, Flygare, Johan, Wong, Piu, Lim, Bing, Lodish, Harvey F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Differentiation Cell Line Cell Nucleus - metabolism Cells, Cultured Down-Regulation Erythroblasts - cytology Erythroblasts - metabolism Gene Knockdown Techniques Mice MicroRNAs - metabolism Protein-Serine-Threonine Kinases - metabolism Research Communication Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Up-Regulation
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