Direct Visualization of Protein Association in Living Cells with Complex-Edited Electron Microscopy

Good partnership: A novel technique called complex‐edited electron microscopy (CE‐EM) combines bipartite tetracysteine display with EM and permits high‐resolution imaging of discrete protein complexes (A and B in the picture). The strategy facilitates the direct and selective labeling of discrete protein complexes in living cells, followed by imaging with the extraordinary resolution of EM.