A biological target for antiplatelet therapy: the prostaglandin E2 receptor EP4

A biological target for antiplatelet therapy: the prostaglandin E2 receptor EP4

[...] an EP4 antagonist enhanced the PGE2-induced stimulation of platelet aggregation, indicating a potent anti-aggregatory activity of the EP4 receptors. Interestingly, the inhibitory effect of the EP4 agonist was brought about by protein kinase C but not adenylyl cyclase, accompanied by attenuated...

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Veröffentlicht in:BMC pharmacology 2010-11, Vol.10 (S1), p.A17-A17, Article A17
Hauptverfasser: Philipose, Sonia, Ofner, Martina, Heinemann, Ákos, Schuligoi, Rufina
Format: Artikel
Sprache:eng
Schlagworte:
Blood clots
Collagen
Flow cytometry
Kinases
Meeting Abstract
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Zusammenfassung:[...] an EP4 antagonist enhanced the PGE2-induced stimulation of platelet aggregation, indicating a potent anti-aggregatory activity of the EP4 receptors. Interestingly, the inhibitory effect of the EP4 agonist was brought about by protein kinase C but not adenylyl cyclase, accompanied by attenuated Ca2+ flux, decreased activation of glycoprotein IIb/IIIa and down-regulation of P-selectin.
ISSN:1471-2210
1471-2210
DOI:10.1186/1471-2210-10-S1-A17