Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index

Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index

Obesity is globally prevalent and highly heritable, but the underlying genetic factors remain largely elusive. To identify genetic loci for obesity-susceptibility, we examined associations between body mass index (BMI) and ~2.8 million SNPs in up to 123,865 individuals, with targeted follow-up of 42...

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Veröffentlicht in:Nature genetics 2010-10, Vol.42 (11), p.937-948
Hauptverfasser: Speliotes, Elizabeth K., Willer, Cristen J., Berndt, Sonja I., Monda, Keri L., Thorleifsson, Gudmar, Jackson, Anne U., Allen, Hana Lango, Lindgren, Cecilia M., Luan, Jian’an, Mägi, Reedik, Randall, Joshua C., Vedantam, Sailaja, Winkler, Thomas W., Qi, Lu, Workalemahu, Tsegaselassie, Heid, Iris M., Steinthorsdottir, Valgerdur, Stringham, Heather M., Weedon, Michael N., Wheeler, Eleanor, Wood, Andrew R., Ferreira, Teresa, Weyant, Robert J., Segré, Ayellet V., Estrada, Karol, Liang, Liming, Nemesh, James, Park, Ju-Hyun, Gustafsson, Stefan, Kilpeläinen, Tuomas O., Yang, Jian, Bouatia-Naji, Nabila, Esko, Tõnu, Feitosa, Mary F., Kutalik, Zoltán, Mangino, Massimo, Raychaudhuri, Soumya, Scherag, Andre, Smith, Albert Vernon, Welch, Ryan, Zhao, Jing Hua, Aben, Katja K., Absher, Devin M., Amin, Najaf, Dixon, Anna L., Fisher, Eva, Glazer, Nicole L., Goddard, Michael E., Heard-Costa, Nancy L., Hoesel, Volker, Hottenga, Jouke-Jan, Johansson, Åsa, Johnson, Toby, Ketkar, Shamika, Lamina, Claudia, Li, Shengxu, Moffatt, Miriam F., Myers, Richard H., Narisu, Narisu, Perry, John R.B., Peters, Marjolein J., Preuss, Michael, Ripatti, Samuli, Rivadeneira, Fernando, Sandholt, Camilla, Scott, Laura J., Timpson, Nicholas J., Tyrer, Jonathan P., van Wingerden, Sophie, Watanabe, Richard M., White, Charles C., Wiklund, Fredrik, Barlassina, Christina, Chasman, Daniel I., Cooper, Matthew N., Jansson, John-Olov, Lawrence, Robert W., Pellikka, Niina, Prokopenko, Inga, Shi, Jianxin, Thiering, Elisabeth, Alavere, Helene, Alibrandi, Maria T. S., Almgren, Peter, Arnold, Alice M., Aspelund, Thor, Atwood, Larry D., Balkau, Beverley, Balmforth, Anthony J., Bennett, Amanda J., Ben-Shlomo, Yoav, Bergman, Richard N., Bergmann, Sven, Biebermann, Heike, Blakemore, Alexandra I.F., Boes, Tanja, Bonnycastle, Lori L., Bornstein, Stefan R., Brown, Morris J., Buchanan, Thomas A.
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Sprache:eng
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Zusammenfassung:Obesity is globally prevalent and highly heritable, but the underlying genetic factors remain largely elusive. To identify genetic loci for obesity-susceptibility, we examined associations between body mass index (BMI) and ~2.8 million SNPs in up to 123,865 individuals, with targeted follow-up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity-susceptibility loci and identified 18 new loci associated with BMI ( P
ISSN:1061-4036
1546-1718
DOI:10.1038/ng.686