Patterned Differentiation of Individual Embryoid Bodies in Spatially Organized 3D Hybrid Microgels

Patterned Differentiation of Individual Embryoid Bodies in Spatially Organized 3D Hybrid Microgels

A microengineered hybrid hydrogel array is developed containing asymmetrical extracellular matrices [polyethylene‐glycol (PEG) and gelatin methacrylate (GelMA)] to mimic the anisotropic stem cell niche and induce the patterned differentiation of embryoid bodies (EBs). The asymmetrical matrices aroun...

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Veröffentlicht in:Advanced materials (Weinheim) 2010-12, Vol.22 (46), p.5276-5281
Hauptverfasser: Qi, Hao, Du, Yanan, Wang, Lianyong, Kaji, Hirokazu, Bae, Hojae, Khademhosseini, Ali
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Differentiation - drug effects
Cell Line
embryoid bodies
Embryoid Bodies - cytology
Embryoid Bodies - drug effects
embryonic stem cells
hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
Mice
microengineering
Microtechnology - instrumentation
polarity
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Zusammenfassung:A microengineered hybrid hydrogel array is developed containing asymmetrical extracellular matrices [polyethylene‐glycol (PEG) and gelatin methacrylate (GelMA)] to mimic the anisotropic stem cell niche and induce the patterned differentiation of embryoid bodies (EBs). The asymmetrical matrices around individual aggregate of mouse EBs induce polarity and demonstrate the potential of microscale engineered materials for forming tissues.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201002873